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This is an update of the third release of ABCISSE (version 3.3).
ABCISSE is a relational database describing the properties and the protein
composition of experimentally investigated ATP-binding cassette (ABC) systems.
In addition, we report complete inventories of the predicted ABC systems
for organisms whose complete genome sequence is known.
In the latter case, ABC proteins and their interacting partners were
identified by comparing the proteomes of these organisms to the full content
of ABCISSE. Systems were reconstructed and sorted in families and subfamilies
according to the phylogenetic and functional classification with was described
in our publications. We predict the polarity of transport,
the substrate specificity and the biological role of these systems.
The database now contains all ABC systems so far identified in the GenBank
database translations on December 2003. The annotation process is manual
and this explains the delay in sequence annotation. To follow the increasing
amount of new genomic sequences, future updates will appear periodically.
For suggestions, corrections, or comments on the annotations, please
contact us.
Philippe Bouige pbouige@pasteur.fr
Elie Dassa elidassa@pasteur.fr
Some statistics on the content of ABCISSE :
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Number of
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Species
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Completed
Genomes
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Systems
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Partners
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906
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276
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13267
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34324
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Our classification is based on, and described in the
following publications.
Bouige P, Laurent D, Piloyan L, Dassa E.
Phylogenetic and functional classification of ATP-binding cassette (ABC)
systems.
Curr Protein Pept Sci. 2002 Oct;3(5):541-59.
Dassa
E, Bouige P.
The ABC of ABCS: a phylogenetic and functional classification of ABC
systems in living organisms.
Res Microbiol. 2001 Apr-May;152(3-4):211-29.
Saurin
W, Hofnung M, Dassa E.
Getting in or out: early segregation between importers and exporters
in the evolution of ATP-binding cassette (ABC) transporters.
J Mol Evol. 1999 Jan;48(1):22-41.
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